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ABL2isaproto-oncogene,locatedonchromosome1q25.2,thatisexpressedinbothnormalandtumorcellsandfunctionsincytoskeletalrearrangements.ItisinvolvedintranslocationwiththeETSVariant6geneinleukemia.Frequenttranslocation,t(1;12)(q25;p13),isassociatedwithacutenon-lymphoblasticleukemia.OtherdiseasesassociatedwiththeABL2geneareacutemyeloidleukemiawitheosinophilia.
OurABL2BreakApartFISHProbecanbeusedtodetectarearrangementoftheABL2gene.Theprobecomeslabeledinorangeandgreen,andyoumayalsochoosetocustomizetheprobetomeetyourneeds.
*USA–ASR,EU–CEMarked(Orange-Greencoloroptiononly)
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Empire Genomics我们的AneuFocus试剂盒可用于识别13号,18号,21号,X和Y染色体非整倍体,它们共同构成了产前病例和新生儿中绝大多数具有临床意义的核型改变。